https://articleseen.com/rss/rssauthor.aspx?auth=dr.rabiaArticleSeen.com - Submit your quality article for maximum exposureCopyright 2009 ArticleSeenhttps://articleseen.com/Article_ly294002-in-pi3k-inhibitor_143378.aspxLy294002 is such an important PI3K inhibitor. Today, I would look back the classic article to review some information. The article “A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)” provides much important information.The article was published on the journal of biological chemistry in 1994. Fri, 03 Feb 2012 01:47:52 GMThttps://articleseen.com/Article_protein-kinase-d3-sensetizes-raf265_143283.aspxIn normal functioning of cells MAP kinase pathway plays a crucial role. When any factor changes this pathway to a hyperactive form, pathways like cellular growth, proliferation, survival and apoptosis are disturbed and it leads to the formation of tumor or cancer. Fri, 03 Feb 2012 00:35:25 GMThttps://articleseen.com/Article_dasatinib-response_136648.aspxPatient selection has always been a laudable goal of targeted therapy and early successes, such as trastuzumab for the treatment of human epidermal growth factor receptor 2–positive breast cancer and imatinib for c-KIT–expressing gastrointestinal stromal tumors, fostered the concept of tailored therapy to enhance response in clinical trials and reduce unnecessary patient exposure to inactive agents. Fri, 20 Jan 2012 00:43:52 GMThttps://articleseen.com/Article_ar-42-functions-against-neurofibromatosis-type-2_136644.aspxHistone deacetylases is the name given to the enzymes responsible of catalyzing the removal of acetyl groups attached to lysine residues. These histone deacetylases have ability of increases the condensation of chromatin material and represses the transcription process. Including this these histone deacetylases causes epigenetic silencing.Fri, 20 Jan 2012 00:40:38 GMThttps://articleseen.com/Article_sorafenib-for-osteosarcoma-cells_136637.aspxTwo vital pathways are stimulated via RTK or receptor tyrosine kinase. These pathways include the PI3K which is progressed through AKT and secondly mitogen activated protein (MAP) kinase pathway which depends on ERK1/2 for its progress. Fri, 20 Jan 2012 00:38:14 GMThttps://articleseen.com/Article_compound-libraries-provide-a-variety-of-compounds-which-can-be-used-to-induce-or-inhibit-apoptosis_135924.aspxIt is the beauty of nature that it keeps a check on each and every reaction taking place within us. There is a discipline not only in the creation of newer entities but there is also decency in the destruction of older ones when not required. The programmed destruction of cells is called as apoptosis.Wed, 18 Jan 2012 23:15:04 GMThttps://articleseen.com/Article_mgcd0103-and-proteasome_135916.aspxThe epigenetic mechanism is involved in the transcription of different genes along with a vital role of HDACs (histone deacetylases). Histones proteins are attached with the DNA in the nucleus and are deacetylated as the acetyl group is dissociated from Lysine residues present in the core of these proteins due to the function of HDACs.Wed, 18 Jan 2012 23:02:56 GMThttps://articleseen.com/Article_role-of-pd0325901-in-mek12-kinase-inhibitor-compound-libraries_135914.aspxVarious mutations are mainly the cause cancer or tumor growth. A good number of pathways have been studied so far in order understand the mechanism of cancer growth and proliferation. Among these pathways the most important one is the Ras originated and to downstream Raf-MEK1/MEK2-ERK1/ERK2.Wed, 18 Jan 2012 23:00:59 GMThttps://articleseen.com/Article_test-of-signaling-pathways-in-cervical-cancer_134652.aspxIn this poster, I would introduce a new article published in cancer research and I wanna to recommend a way to discovery the relationship between gene expression and cancer in vivo. Researchers in this article just gave an example and we could do more study in similar way in future.Mon, 16 Jan 2012 23:52:39 GMThttps://articleseen.com/Article_target-focused-compound-libraries-are-based-on-the-designing-of-inhibitors_134537.aspxPresently a wide range of approaches are available for the high throughput screening of compound libraries. Broadly the screening may be target oriented or diversity oriented screening. The high cost of screening whit lesser chances of successful hits is the main bottleneck in exponential rate of screening. Target focused approach eases this bottleneck to a greater extent. Mon, 16 Jan 2012 20:43:33 GMThttps://articleseen.com/Article_in-vx-745is-the-p38-it-is-responsible-for-the-stimulation-of-various-inflammatory-responses_134249.aspxThere are good numbers of intracellular signaling pathways are activated in response to extracellular stimuli. Amongst all these important signaling pathways the MAPK (kinase of mitogen activated protein) is one of the vital pathways. In this it the p38 it is responsible for the stimulation of various inflammatory responses by activating the inflammatory mediators. Kinase inhibitors are very effective against the it pathway.Mon, 16 Jan 2012 03:23:21 GMThttps://articleseen.com/Article_study-and-research-of-foretinib-in-renal-cell-carcinoma_133381.aspxForetinib, in advanced metastatic solid tumors. Foretinib was identified by high-throughput screening and rationally developed to act as both a proliferation inhibitor (Met) and an angiogenesis inhibitor (VEGFR) in order to test the hypothesis that antitumor activity could be combined in a single agent. Fri, 13 Jan 2012 04:16:27 GMThttps://articleseen.com/Article_autodock-as-an-example-of-cloud-computing-in-hts_133122.aspxHigh throughput screening technology is no more straight forward and conventional as it was in the early period of discovery. Since its discovery in 1990s’ a lot of modifications have been imparted to improve the parameters of HTS.Fri, 13 Jan 2012 00:20:07 GMThttps://articleseen.com/Article_foretinib-inhibits-both-met-and-vegfr-in-a-balanced-manner_132691.aspxThe role of mesechymal-epithelial transition (Met) tyrosine kinase in various cancers has been discussed in previous posts. Briefly, Met is one of the most frequently dysregulated pathways in human cancers. Patients with constitutively active Met tend of have aggressive cancers that are resistant to chemotherapy and, therefore, carry poor prognoses.Thu, 12 Jan 2012 03:20:03 GMThttps://articleseen.com/Article_laq824-targets-regulators-of-cell-cycle-and-growth_131302.aspxHDAC inhibitors have great potential to destroy tumor and cancer cells. LAQ824 is one of HDAC inhibitors as different animal xenografts had depicted the role of this compound during various experiments. The mechanism of action is similar as in other such inhibitors. The LAQ824 arrest the growth of cell by cell cycle arrest or inducing apoptosis. Tue, 10 Jan 2012 02:12:20 GMThttps://articleseen.com/Article_phosphorylation-pathway-of-erk5-is-inhibited-by-bix02189_131113.aspxERK5 is an important MAPK family member. It must be in activated form for the proper growth and maintenance of the neuronal cells and tissues. Phosphorylation pathway of ERK5 is inhibited by BIX02189. And this BIX 02189 is an effective key to analyze the function of ERK5 and the pathways activated by it. Molecular size of ERK1/2 is half of the size of ERK5 indeed while the amino terminals of both are almost homologous.Mon, 09 Jan 2012 23:32:43 GMThttps://articleseen.com/Article_entinostat-performs-almost-similar-functions-as-belinostat-and-panobinostat_130894.aspxEntinostat, is also known with different other names such as MS-275, SNDX-275 and MS-27-275. This compound is among HDAC inhibitors and is selective for HDAC1 and HDAC3. It performs almost similar functions as Belinostat and Panobinostat which are HDAC inhibitors. In human beings under in vivo conditions Entinostat is known to show a great anti tumor activity.Mon, 09 Jan 2012 05:39:08 GMThttps://articleseen.com/Article_bix-02188-for-steady-flow_130738.aspxA steady blood flow is the only case of prevention of atherosclerosis. A shear stress can cause the prevention of hardening of blood vessels. So when a shear stress is exerted by flow of fluid, it results in the in vivo prevention of atherosclerosis. Atherosclerosis leading to oxidative stress also accompanied with expression of VCAM1 increased inflammation.Mon, 09 Jan 2012 03:29:10 GMThttps://articleseen.com/Article_ar-42-hdac-42-in-the-inhibition-of-various-cancer-cells_128559.aspxAR-42 is a new histone deacetylase inhibitor like vorinostat which regulates apoptosis via different pathways. It affects different cell cycle stages leading to the inhibition of cell proliferation in an effective manner. Proteins like tubulin and histones are also affected by this inhibitor.Wed, 04 Jan 2012 04:59:33 GMThttps://articleseen.com/Article_cudc-101-is-an-inhibitor-with-multiple-targets_128535.aspxCUDC-101 is a novel compound which inhibits multiple targets. The effect of this inhibitor is on variety of protein groups for example receptors of kinases, different growth factor receptors like EGFR and HER2, in tumor cells. This is an efficient inhibitor of both classes of HDACs (class I and II).Wed, 04 Jan 2012 04:33:58 GMThttps://articleseen.com/Article_computational-approach-for-hts-qsar_127455.aspxHigh throughput screening has become the leading tool in drug discovery. With its fundamentals of sample collection with subsequent screening to find hits to generate optimized leads, HTS is proving to be a useful source of expanding compound libraries. Mon, 02 Jan 2012 05:15:59 GMThttps://articleseen.com/Article_regorafenib-inhibits-multiple-kinases-and-controls-the-process-of-angiogenesis-efficiently_123584.aspxA tumor needs a continuous blood supply for its growth beyond 1-2mm in dimension. The process of angiogenesis is related with the development of new blood vessels from the older ones and this process maintains a constant supply of oxygen to the growing tumor. The members belonging to the VEGF family promote the process of angiogenesis.Fri, 23 Dec 2011 02:48:10 GMThttps://articleseen.com/Article_development-of-high-throughput-screening-technology_123580.aspxHigh throughput screening technology has played a key role in the development of inhibitors against particular targets via in vitro assays. However every inhibitor cannot be used directly as a drug. Fri, 23 Dec 2011 02:45:48 GMThttps://articleseen.com/Article_the-process-of-hts-becomes-useful-only-when-the-results-of-screening-analysis-are-visualized_123578.aspxThe key strategy of drug development in the contemporary era involves the screening of compound libraries. The process of HTS becomes useful only when the results of screening analysis are visualized. This visualization is accomplished by performing high quality HTS assays which employ certain radioactive, fluorescence or other biophysical methods to see the changes. Fri, 23 Dec 2011 02:43:21 GMThttps://articleseen.com/Article_role-of-bix02188-in-the-study-of-erk5_101841.aspxBeing a potent inhibitor of ERK5 and MEK5, BIX02188 helped in the study of the effects of steady flow of blood. It also helped to prove that ERK5 is very essential for the growth of the neuronal tissues.Wed, 09 Nov 2011 00:41:36 GMT