Dr.rabia's Article in Health and Fitness
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347
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PROTEIN KINASE D3 SENSETIZES RAF265
In normal functioning of cells MAP kinase pathway plays a crucial role. When any factor changes this pathway to a hyperactive form, pathways like cellular growth, proliferation, survival and apoptosis are disturbed and it leads to the formation of tumor or cancer.
Posted on Feb-03-2012
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498
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Dasatinib response
Patient selection has always been a laudable goal of targeted therapy and early successes, such as trastuzumab for the treatment of human epidermal growth factor receptor 2–positive breast cancer and imatinib for c-KIT–expressing gastrointestinal stromal tumors, fostered the concept of tailored therapy to enhance response in clinical trials and reduce unnecessary patient exposure to inactive agents.
Posted on Jan-20-2012
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332
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SORAFENIB FOR OSTEOSARCOMA CELLS
Two vital pathways are stimulated via RTK or receptor tyrosine kinase. These pathways include the PI3K which is progressed through AKT and secondly mitogen activated protein (MAP) kinase pathway which depends on ERK1/2 for its progress.
Posted on Jan-20-2012
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291
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MGCD0103 AND PROTEASOME
The epigenetic mechanism is involved in the transcription of different genes along with a vital role of HDACs (histone deacetylases). Histones proteins are attached with the DNA in the nucleus and are deacetylated as the acetyl group is dissociated from Lysine residues present in the core of these proteins due to the function of HDACs.
Posted on Jan-18-2012
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